Endocrine Abstracts

Introduction: Eligibility for bariatric surgery in the Unighted Kingdom is based on specific body mass index (BMI) thresholds and the presence of obesity-associated complications. Patients with partial lipodystrophy (LD) often have an abundance of metabolic and cardiovascular complications, but their abdominal adiposity does not always substantially increase BMI. The consequence is that patients with LD may be inappropriately excluded from obesity treatments when judged by BMI...

Introduction: Vaccine-induced thrombosis and thrombocytopenia (VITT) after vaccination against SARS-CoV-2 with the adenoviral vector-based vaccines ChAdOx1 and Ad26.COV2.S has been associated with adrenal pathology, such as bilateral adrenal vein thrombosis, adrenal cortex haemorrhage and adrenal insufficiency in six percent of patients1.Case report: We report the case of a 23-year-old healthy woman who presented at eight days after ChAdOx1 va...

Case History: We report the case of a 23-year-old woman who developed adrenal insufficiency secondary to bilateral adrenal haemorrhage in the context of vaccine-induced thrombosis and thrombocytopenia (VITT). She presented with breathlessness and chest pain eight days after receiving her first dose of the adenoviral vector-based ChAdOx1 vaccine. Over the course of a week, she developed fulminant VITT. Her only comorbidity was obesity, with BMI of 35 kg/m2. <p class="abstex...

History: We present the case of a 47-year-old man with heart failure (HF) and cranial diabetes insipidus (CDI) secondary to Langerhans-cell-histiocytosis. In the context of worsening HF with increasing shortness of breath and fluid retention, careful desmopressin dose reduction provided adequate aquaresis to restore euvolemia, obviating the need for usual diuretic treatments.Investigations: Echocardiography and a cardiac MRI revealed a non-dilated but se...

Background: To date, there is no consensus as to the gold-standard screening test for diagnosing Cushing’s Syndrome (CS).Objectives: This study aimed to: a) compare the ability of late-night salivary cortisol (LNSC) against overnight dexamethasone suppression test (ONDT) and urinary free cortisol (UFC) as screening test for pathological hypercortisolism (PH); b) test the performance of those tests in diagnosing Cushing’s disease (CD) or mild au...

Introduction: The incidence of the syndrome of inappropriate antidiuresis (SIAD) post pituitary surgery is estimated at 3-20% with the condition potentially leading to significant morbidity and prolonged admission. Copeptin, a surrogate marker for vasopressin activity, has been shown to be a diagnostic tool in the diagnosis of AVP deficiency (formerly known as diabetes insipidus) post pituitary surgery. There is limited data regarding the utility of copeptin in predicting SIAD...